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Buy JWH-018 powder online, a synthetic cannabinoid

Synthetic cannabinoids are synthetic molecules that act in a way similar to that of plant cannabinoids, naturally present in cannabis (such as THC).

They are primarily cannabinoid receptor agonists. Most were developed for therapeutic purposes (analgesia), others were synthesized with the aim of creating legal alternatives to cannabis.

Synthetic cannabinoids are the most important class of new synthetic products . Of the 73 new synthetic substances reported by the EMCDDA in 2012, 30 were synthetic cannabinoids

The first "synthetic cannabis" was in the form of a mixture of various plants that had been impregnated with synthetic cannabinoids.

 It appeared in the mid-2000s as Spice [3] ( Spice Gold , Spice Silver ...). Other brands then appeared ( K2 , Yucatan Fire , etc…). These products only really gained popularity from the second half of the 2000s.

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nb= For those who knew the saga of "Dune" by Franck Herbert, the name "Spice" was given in reference to the "Spice" of the science fiction novel, the spice produced by the planet Arrakis, which increased the psychic abilities and allowed interstellar travel, for example.

At the end of 2008, analyzes detected the presence of synthetic cannabinoids in these mixtures, in particular CP-47,497-C8 and JWH-018. Following measures to ban these compounds in several countries, manufacturers will then use new molecules. In 2009, other synthetic cannabinoids such as JWH-073, JWH-019, JWH-250, JWH-398 and HU-210 will be identified . Other new compounds will be regularly identified thereafter.

Most synthetic cannabinoid powders that are used in “legal highs” are manufactured in China and then shipped in bulk through legal transportation and distribution networks. 

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Shipments of several kilos are often intercepted by European authorities, but purity is rarely determined. A study in South Korea reported purities between 75% and 90% on bulk powder samples. European seizures of bulk powders include 54 kilograms of JWH-018 in Denmark (2012), 21 kilograms of JWH-018 in Finland (2012) and 20 kilograms of AM-2201 in Spain (2013).

Once in Europe, the products are mixed with herbs. This form is primarily intended for smoking. Among the grasses used as a carrier, the following species can be mentioned: Canavalia maritima , Nymphaea caerulea , Scutellaria nana , Pedicularis densiflora , Leonotis leonurus , Zornia latifolia , Nelumbo nucifera or Leonurus sibiricus

Other types of research chemical substances have also been identified in some samples

fatty acid derivatives with effects similar to cannabinoids: oleamide, palmitamide, stearamide

MAOIs: harmine, harmaline

an opioid: O-desmethyltramadol

other molecules, some of which come from the plants used as a support and others which would have been added

Today, CS is no longer found only within herbal smoking blends but can be obtained as an isolated powder from some RC suppliers. They can also be found in resin form (like the Bang Solid or Afghan Insense brands) in response to the growing popularity of cannabis resin in many countries. It can also be found in some e-liquids for electronic cigarettes.

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Many of the synthetic cannabinoids have code names that relate to their discovery. In some cases, their code name comes from the initials of the name of the scientists who first synthesized them: the "JWH" compounds come from John W. Huffman, the "AM" compounds come from Alexandros Makriyannis. In other cases, they may come from the company where they were synthesized: the “HU” series comes from the Hebrew University of Jerusalem, the CP series was created by the Pfizer laboratory.

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Others may have codenames derived from their chemical name: APICA for N-(1-adamantyl)-1-pentyl-1H-indole-3-carboxamide or APINACA for N-(1-adamantyl)-1-pentyl -1H-indazole-3-carboxamide

More recently, those involved in the "legal high" business have started using code names that were likely chosen to help market the products. For example, AKB-48 is another used name of APINACA. AKB-48 is the name of a popular Japanese girl group that has been compared to British pop group 'Spice Girls'. The synthetic cannabinoid APICA is also referred to by the alternate name of "2NE1", which is the name of a South Korean girl group that has also been compared to the Spice Girls.

 Finally, the synthetic cannabinoid XLR-11, appears to have been named after the first liquid fuel developed in the United States for use in airplanes.

Synthetic cannabinoids have various structures. We can distinguish 

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THC and some examples of CS

Naphthoylindoles:

JWH-007, JWH-015, JWH-018, JWH-019, JWH-073, JWH-081, JWH-098, JWH-116, JWH-122, JWH-149, JWH-182, JWH-193, JWH- 198, JWH-200, JWH-210, JWH-398, JWH-424, AM-1220, AM-1221, AM-1235, AM-2201, AM-2232, MAM-2201

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HU-210 is a synthetic agonist analog of Δ9-THC, which is the primary psychoactive component of marijuana. HU-210 is a potent central cannabinoid (CB1) 

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